Balanced DHEA + Pregnenolone 1:1 | Hormone & Adrenal Support

QUALITY BENEFITS DETAILS HOW TO USE

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: Varies

Amount Per Serving	% Daily Value*
DHEA (Micronized) 25 mg	†
Pregnenolone 25 mg	†

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: Mannitol, Cellulose Capsule

Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, & Corn.

Directions: As a dietary supplement, take one capsule daily with water alongside a meal containing healthy fats for maximum absorption or as directed by a physician.

Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS OR WOMEN. Consult a physician before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased estrogen levels. Discontinue use and call a physician immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Keep out of reach of children.

Tested By Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Provides the primary building blocks for steroid hormone synthesis
Supports adrenal health and a balanced stress response
Promotes long-term endocrine health and adaptive aging
Encourages healthy neurosteroid levels to support memory and mental clarity
Works with the body's existing processes to sustain hormonal equilibrium.
Assists in maintaining stable mood and daily energy levels

What is DHEA (Dehydroepiandrosterone)?

DHEA is a naturally occurring steroid hormone that serves as a vital precursor to other hormones within the human body. Primarily manufactured by the adrenal glands, though also produced in the brain and reproductive organs, it acts as the essential raw material the endocrine system uses to create other critical hormones, such as testosterone and estrogen.

The Age-Hormone Connection

Research shows that DHEA production follows a specific lifecycle:

The Peak: Levels typically reach their height during a person's early 20s.

The Decline: Natural DHEA output steadily diminishes with age.

The Long-Term Effects: Studies have linked this gradual reduction to shifts in metabolic rate, physical stamina, immune system efficiency, and overall mental clarity.

A Powerful Neurosteroid

Beyond its role in systemic hormone balance, DHEA is a potent neurosteroid. It is uniquely active within the central nervous system, modulating how the brain responds to stress and manages neurotransmitter signals. By supporting neuronal resilience, DHEA helps the brain maintain its cognitive flexibility and recover more effectively from the taxing effects of external stressors or trauma.

What is Pregnenolone?

Pregnenolone, also known as the mother hormone within the human endocrine system, is the initial steroid hormone synthesized from cholesterol. It sits at the top of the hormonal hierarchy and acts as the main starting point for nearly all other essential steroid hormones.

The Steroidogenesis Cascade

Pregnenolone synthesis is the critical first step in producing a wide array of vital compounds, including:

DHEA and Progesterone
Androgens (Testosterone) and Estrogens
Corticosteroids (Cortisol and Aldosterone)

Pregnenolone production occurs within the adrenal glands, gonads, and the brain. It operates as a neurosteroid within the central nervous system, where it facilitates several biological functions, including:

Memory formation and information processing
Nervous system communication
Modulating physiological and psychological stress responses

Maintaining sufficient levels of pregnenolone is essential for achieving comprehensive hormonal balance. Because it acts as the origin point for the entire steroidogenesis process, its availability ensures that the endocrine system can maintain a dynamic and responsive state, effectively managing the transition of precursors into active hormones as bodily demands shift.

A Balanced Approach to Hormone Support

This formula uses a 1:1 ratio of DHEA and pregnenolone (25 mg each) to provide a steady, moderate foundation for the body’s natural hormone pathways. Rather than overloading the system with a high dose of a single precursor, this balanced blend gives the endocrine system the raw materials it needs to function in equal amounts. The blend also includes mannitol to ensure each capsule provides consistent, reliable support.

Potential DHEA and Pregnenolone Benefits

Promotes Adrenal Function and Stress Modulation

DHEA and pregnenolone serve as fundamental components of the adrenal matrix. These precursors provide the biological scaffolding necessary for the adrenal glands to manage the demands of physical and psychological pressure. By supplying the essential precursors for cortisol and related steroidal compounds, these molecules facilitate a more robust and adaptive stress response.

Endocrine Flexibility via Precursor Availability

Rather than introducing end-stage hormones into the system, which can bypass natural regulatory loops, DHEA and pregnenolone function as raw metabolic materials. This precursor-based strategy enables the body to synthesize specific hormones in response to real-time physiological needs. Such an approach supports the endocrine system's endogenous regulation and its ability to maintain homeostatic balance.

Supports Neurosteroid Activity and Cognition

As active neurosteroids, both compounds exert a direct influence on the central nervous system. They modulate synaptic plasticity and neurotransmitter equilibrium, specifically targeting the GABAergic and glutamatergic signaling pathways. Data suggests that these interactions are vital for memory consolidation, mental sharpness, and neurological resilience.

Biological Support for Healthy Aging

The natural depletion of these steroidal precursors over time often coincides with shifts in metabolic efficiency, immune response, and neurological health. Supplementation aims to reinforce the physiological pathways that typically diminish with age. By replenishing these foundational building blocks, it is possible to support the systemic vitality and well-being that rely on consistent hormonal availability.

Influence on Mood and Metabolic Energy

Stabilizing neurosteroid levels and adrenal output has an indirect but significant effect on emotional state and perceived energy. In populations experiencing age-related hormonal decline, maintaining these precursor levels supports consistent motivation, mood stability, and the metabolic processes required for sustained physical energy.

Potential DHEA and Pregnenolone Side Effects

Most individuals maintain high tolerability for DHEA and pregnenolone when following recommended protocols. Because DHEA and pregnenolone influence hormone pathways, some individuals may experience:

Oily skin or acne
Irritability or restlessness
Sleep changes
Headache
Mild digestive discomfort
Libido changes

Individuals who are pregnant, breastfeeding, or managing hormone-sensitive health conditions should talk to a doctor before starting these supplements. Additionally, people taking medications that influence the endocrine system or intending to take this product long-term should seek qualified professional supervision.

References

Solubility: Fat-soluble.

When to Take: The body naturally produces these hormones in the early morning hours. Taking the supplement early in the day helps mimic natural circadian, adrenal, and cortisol rhythms.

What to take with: While the body can absorb DHEA and pregnenolone on an empty stomach, taking them with a meal—specifically one that contains healthy fats—maximizes absorption. Additionally, taking this supplement blend with a meal may help prevent any mild stomach discomfort.

Spoon Set or Scale Needed?

Individuals do not need measuring tools, as DHEA +
Pregnenolone 1:1 comes in pre-measured capsules.