What is Inositol Hexanicotinate?
Inositol hexanicotinate, also known as inositol nicotinate, is a nutritional supplement commonly taken as a flush-free niacin (vitamin B3) analog.
This compound is inositol esterified with niacin. Niacin is an important vitamin, but is associated with what is termed a "niacin flush" because it increases blood flow in the body.
After using niacin, many users report "flushing" as vitamin B3 causes a dilation of the blood vessels. Flushing is characterized by tingling and itching sensations, skin redness or warmth, sweating, shortness of breath, increased heart rate, chills, dizziness and even fainting. Inositol hexanicotinate, on the other hand, allows for true niacin activity without niacin's characteristic flush.
Inositol, also referred to as vitamin B8, is a water-soluble fatty lipid needed for the formation and maintenance of healthy cells. Inositol helps niacin perform its functions more effectively.
The role of Niacin
Niacin is a vital, water-soluble vitamin, also known as Vitamin B3. It is also called niacin, nicotinic acid, nicotinamide and niacinamide. Niacin is one of the most stable of the B vitamins (Wikipedia). It is resistant to the effects of heat, light, air, acid and alkali. Niacin and niacinamide are white crystalline substances soluble in both water and alcohol. They are both readily absorbed from the small intestine. Small amounts may be kept in the liver, while most of the excess is excreted in the urine.
Niacin plays a key role in clearing the body of toxic and harmful chemicals. It helps synthesize hormones in the adrenal glands and other parts of the body. Vitamin B3 is needed for the action enzymes that catalyze or speed up chemical reactions. These enzymes are responsible for generating energy in the body, breaking down dietary fats, the creation of certain hormones and cholesterol, the processing of genetic material (DNA) and the growth and maturation of the cells in the body.
Niacin needs can be met partially by incorporating high protein foods in the diet because the human body is able to convert tryptophan, an amino acid, into niacin. Niacin, through its analogs, is involved in a variety of metabolic and biological processes, including energy production, fatty acid synthesis, signal transduction, the management of gene expression and the maintenance of genomic integrity.
Purity and Concentration of Inositol Hexanicotinate
Purebulk's Inositol Hexanicotinate powder contains no fillers, additives or anti-caking agents.
Potential Side Effects of Inositol Hexanicotinate
Inositol Hexanicotinate seems to be safe for most people. It can cause some side effects such as stomach upset, headache, nausea, burping and hiccups. It can cause liver damage if taken in excessive amounts. Those taking prescription drugs to treat high cholesterol or elevated blood lipid levels should consult the prescribing physician before taking this product. If you have a heart condition, diabetes, kidney problems or liver disease, check with a health care provider before using inositol hexanicotinate. Use of Inositol Hexanicotinate supplementation during pregnancy or breastfeeding is not recommended.
How should I store it?
You will receive a resealable bag of this powder. Store in a cool, dry area protected from light. Reseal after each use.
References & Further Research
Linus Pauling Institute, Micronutrient Information Center: Niacin
National Center for Complementary and Alternative Medicine: Vitamins and Minerals
NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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