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Melatonin

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Supplement Facts & Directions

Supplement Facts

Serving Size: 3 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Melatonin 3mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive.    Please call for exact numbers.

Other Ingredients: None

Contains:

Free of:  Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.

Directions:  As a dietary supplement, take 1 to 3mg before bedtime, or as directed by physician. Accurate gram weight scale recommended.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Store in a cool, dark & dry place.

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Product Details

What is Melatonin?

Melatonin is a hormone synthesized and secreted by the pineal gland each night that affects the body's circadia rhythm (sleep pattern).

The pineal gland functions as the timekeeper of the brain, helping manage the sleep-wake cycle. Melatonin production in the body is triggered by darkness and inhibited by light, helping the body manage its natural sleep rhythm.

Discovered in the 1950s as a neurohormone (N-acetyl-5 methoxytryptamine) produced in the brain by the pineal gland from the amino acid tryptophan, melatonin became available as a dietary supplement in 1994.

The precursor of melatonin, tryptophan (L-tryptophan), is an essential amino acid synthesized from proteins during digestion via the action of proteolytic enzymes. During the day. it is converted to serotonin (a brain chemical involved with mood) before being converted to melatonin.

Melatonin has also been demonstrated to have powerful antioxidant properties, protecting cells from damage caused by free radical molecules.

Purity and Concentration of Melatonin

This melatonin is a pure powder with no fillers, additives or anti-caking agents. Store in a cool, dry, dark area away from any heat source of direct sunlight.

Note: It is always recommended to verify these measurements with an accurate digital scale.

Warning: The amounts indicated in this table greatly exceed the recommended serving amount.
Measuring Spoon Size Miligrams of Melatonin
1/32 tsp 73mg
1/64 tsp 36mg

Potential Side Effects of Melatonin

Melatonin should not be taken by people using certain antidepressants, such as Prozac (a serotonin inhibitor) or Nardil (a monoamine oxidase inhibitor). Interaction between melatonin and these types of antidepressants can cause a stroke or heart attack. Preliminary symptoms include confusion, sweating, shaking, fever, lack of coordination, elevated blood pressure, diarrhea and convulsions.

Melatonin should only be taken before sleep. Vivid dreams and morning grogginess are common melatonin side effects on daily serving sizes greater than 0.5 milligrams. People taking blood thinners, antiseizure drugs, blood pressure medications, diabetes medications or hormone replacements should avoid melatonin supplements, as they may interfere with the effectiveness of these medications. This product is not recommended for pregnant or nursing women.

 

Bioavailability, Mixing and Solubility

 

Melatonin is practically insoluble in water however, it is however easily dissolved in ethanol. 

 

 

 

References & Further Research

University of Maryland Medical Center: Melatonin

WebMD: Melatonin

The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits.

Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.