43 items left

Looking for bulk options? Click Here

Product Details

What is Methylcobalamin (Methylated B12 Supplement)?

Methylcobalamin is the active, naturally occurring form of vitamin B12. It is highly bioavailable, meaning the body can absorb it easily. Methylated B12 supplements contain a methyl group (CH3) and are ready for use in essential biochemical processes, as the body does not have to convert them first. Vitamin B12 is crucial for nerve cell health, DNA synthesis, red blood cell formation, and metabolizing fatty acids and amino acids. B12's function as a coenzyme in protein and fat metabolism is integral to converting these macronutrients into energy. It ensures that the body processes amino acids from proteins and fatty acids from fats efficiently to generate ATP, the primary energy source for cells.

Rich dietary sources include animal products like meat, fish, eggs, and dairy. Individuals following plant-based diets who avoid dairy and eggs have an increased risk of developing vitamin B12 deficiency. B12 deficiency can lead to fatigue, weakness, pale skin, neurological symptoms like numbness or tingling in the hands and feet, difficulty walking, memory problems, and mood changes. Long-term deficiency can lead to significant health complications such as nerve damage, anemia, and cognitive impairment.

Vitamin B12 Methylcobalamin vs. Cyanocobalamin

Methylcobalamin and cyanocobalamin are almost identical compounds, except for their cobalt ion attachment. Methylcobalamin has a methyl group attached to its cobalt ion, whereas cyanocobalamin has a cyanide molecule. The amount of cyanide present in cyanocobalamin supplements is extremely low and considered safe for consumption. In fact, the cyanide content is significantly lower than what occurs in many foods naturally. The body also has natural detoxification mechanisms to process and eliminate cyanide. Numerous studies consistently show that the low cyanide levels in cyanocobalamin supplements do not pose a significant risk to human health when taken as directed.

The body must convert cyanocobalamin into methylcobalamin or adenosylcobalamin (another active B12 form) before it can utilize it. The conversion process involves enzymes and may vary in efficiency among individuals. Methylcobalamin is already in its active form and does not require conversion before the body can use it for energy production, DNA synthesis, neurotransmitter function, and more.

Vitamin B12 Methylcobalamin Benefits

  • Supports Energy Production: Methylcobalamin helps synthesize red blood cells, which are responsible for carrying oxygen throughout the body. Sufficient oxygen levels are essential for cellular energy production. It also facilitates fatty acid and amino acid metabolism for energy. It ensures that cells have the necessary substrates and cofactors to generate ATP and meet energy demands.
  • Neurological Health: Methylcobalamin is essential for maintaining a healthy nervous system, supporting cognitive function, and contributing to nerve cell health and regeneration. Vitamin B12 supports the healthy functioning of the nervous system, including nerve cell communication and myelin sheath formation.
  • Mood and Well-Being: Methylcobalamin significantly influences mood regulation and overall well-being. Vitamin B12 is essential for synthesizing serotonin and dopamine neurotransmitters that facilitate mood regulation, happiness, and motivation.
  • Heart Health: Methylcobalamin helps regulate homocysteine levels in the blood. Too much homocysteine can increase cardiovascular disease risk. Vitamin B12 helps maintain healthy blood vessels and reduces the risk of arterial damage and plaque formation by converting homocysteine into methionine.
  • Methylcobalamin Vitamin B12 Side Effects

    Vitamin B12 is a water-soluble essential vitamin that is crucial for multiple bodily processes and functions. It is safe to take up to the recommended daily allowance (RDA). Even at higher doses, vitamin B12 is generally safe due to its water-solubility and the body's ability to excrete excess amounts through urine. However, exceeding recommended daily allowances may lead to mild side effects like nausea and headaches.

References and Research



Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Purchase options
Select a purchase option to pre order this product
Countdown header
Countdown message