PureBulk, Inc.

Methylcobalamin 1%

$5.95
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Container: Bag
Size: 25 grams
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Supplement Facts

Serving Size: 200 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Vitamin B12 (as Methylcobalamin) 2000 mcg 83333%

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: Mannitol

Contains:

Free of: Added Sugar, Soy, Dairy, Yeast, Gluten & Corn.

Directions: As a dietary supplement, take 200 mg (1/16 tsp) once daily, or as directed by a physician. An accurate gram weight scale is recommended.

Warning: If you are pregnant, nursing, taking any medications or have any medical conditions, consult your physician before use. Potentially toxic in higher amounts. Use extreme care when measuring. Keep out of reach of children.

Tested By Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found  here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  • Supports energy production and reduces fatigue
  • Promotes nervous system and brain health
  • Helps maintain memory and cognitive clarity
  • Aids red blood cell production and oxygen delivery
  • Supports DNA synthesis and healthy methylation
  • Helps regulate homocysteine for cardiovascular health

What is Methylcobalamin (Vitamin B12)?

Methylcobalamin is a biologically active form of vitamin B12, a water-soluble essential vitamin. It’s critical for energy metabolism, neurological health, and the formation of red blood cells. Unlike cyanocobalamin, which requires conversion in the body, methylcobalamin is a coenzyme form that participates directly in key cellular reactions.

Vitamin B12 is especially critical for maintaining healthy nerve function and for synthesizing DNA and neurotransmitters. Since humans cannot produce vitamin B12 innately, adequate intake through diet or supplementation is necessary.

Who is at Risk for Vitamin B12 Deficiency?

Some individuals are at a higher risk of developing vitamin B12 deficiencies, including:

  • Older Adults: The ability to absorb vitamin B12 can decrease with age.
  • Vegetarians and Vegans: Since B12 is primarily found in animal products, those on strict plant-based diets may need to take supplements or consume fortified foods to meet their daily requirements.
  • Individuals with Certain Medical Conditions: Conditions such as Celiac disease and Crohn's disease can interfere with B12 absorption. Individuals who have undergone gastric surgery may also have difficulties absorbing sufficient vitamin B12 through food sources alone.

Methylcobalamin vs. Cyanocobalamin

While both are supplemental forms of vitamin B12, they differ in how the body processes them:

  • Methylcobalamin: Already in its active coenzyme form, making it more readily available for biological use, particularly in nerve and brain function.
  • Cyanocobalamin: A synthetic form that requires conversion in the liver to methylcobalamin or adenosylcobalamin before the body can use it.
  • Absorption and retention: Studies show that methylcobalamin may have superior tissue retention and is often preferred for neurological health.

Methylcobalamin (Vitamin B12) Benefits

Supports Cellular Energy Production

Vitamin B12 plays a key role in converting dietary carbohydrates, fats, and proteins into adenosine triphosphate (ATP), the universal energy currency of cells. Methylcobalamin also supports mitochondrial function to sustain steady physical and mental energy throughout the day. Deficiency can result in fatigue, weakness, and decreased exercise tolerance.

Maintains Nervous System Health

Methylcobalamin is critical for preserving the integrity of the nervous system. It supports the synthesis of myelin, the protective sheath around nerve fibers that enables efficient signal transmission. Damage to or loss of myelin can lead to neurological problems such as numbness, tingling, or neuropathic pain. Clinical studies suggest methylcobalamin supplementation may help protect against peripheral neuropathy and support nerve repair, making it a preferred form of vitamin B12 for neurological health.

Promotes Cognitive Function

Adequate vitamin B12 levels may help preserve memory, focus, and mental clarity. Methylcobalamin helps synthesize neurotransmitters such as serotonin and dopamine, which influence emotional balance and mental clarity. Research shows that low vitamin B12 levels are associated with cognitive decline, impaired concentration, and an increased risk of age-related neurological disorders. Supplementation with methylcobalamin may help preserve brain function, improve memory retention, and support long-term cognitive resilience.

Red Blood Cell Formation

Vitamin B12 is essential for the production and maturation of red blood cells. Without adequate B12, abnormally large red blood cells (megaloblasts) can form, leading to megaloblastic anemia. This condition reduces oxygen-carrying capacity and can cause symptoms such as weakness, shortness of breath, and pale skin. By supporting healthy red blood cell production, methylcobalamin ensures efficient oxygen delivery to tissues, helping to maintain endurance, vitality, and overall systemic health.

DNA and Methylation Support

Methylcobalamin is a critical methyl donor for converting homocysteine into methionine, a reaction that fuels DNA synthesis and methylation processes. These processes regulate gene expression, protein synthesis, and cellular repair mechanisms. Healthy methylation is crucial for maintaining cardiovascular health, neurological balance, and effective detoxification pathways. Methylcobalamin supports genetic stability and optimal cellular function by contributing to this essential biochemical cycle.

Cardiovascular Support

Elevated homocysteine is a known risk factor for cardiovascular disease. Methylcobalamin, together with folate and vitamin B6, helps convert homocysteine to methionine, thereby reducing circulating levels of this potentially harmful amino acid. Maintaining balanced homocysteine levels supports arterial health, blood flow, and cardiovascular resilience, making vitamin B12 a valuable nutrient for long-term heart and vascular wellness.

Methylcobalamin (Vitamin B12) Side Effects

Vitamin B12 is very safe due to its water-soluble nature. The body absorbs what it needs and excretes any excess through the urine. Side effects are rare but may include mild digestive discomfort (such as nausea and diarrhea), headaches, or dizziness in sensitive individuals.

Individuals with medical conditions or those taking prescription medications should consult a healthcare professional before taking any new supplements.

References

How to Use:

  • Solubility: Water-soluble
  • What to take with: Individuals should take methylcobalamin supplements with a full glass of water.
  • When to take: It is best to take methylcobalamin in the morning, as vitamin B12 may increase energy and alertness.

Spoon Set or Scale Needed?

Use measuring spoons for approximate servings or a milligram scale for precision.