What is Nattokinase?
Nattokinase is an enzyme byproduct obtained by fermenting Nattō with Bacillus subtilis
Nattō is a popular boiled soybean food product in Japan. However, the aroma, flavor, and
consistency can be
off-putting for some. Taking nattokinase supplements provides many of the nutritive benefits of
without the slimy texture. Despite its name, nattokinase is not a kinase enzyme. The name
derives from the
Japanese name for Bacillus subtilis natto, nattōkin.
Nattokinase is the most well-researched protease enzyme. These enzymes catalyze the breakdown of
form new protein products. Proteases also help digest proteins, catabolize proteins, and
participate in cell
signaling. Without proteases, breaking down proteins (proteolysis) would take hundreds of years.
is critical for digestion, and all living organisms need it for growth. Digestion usually
but nattokinase can remain active when taken orally.
Potential Nattokinase Benefits
Nattokinase and Heart Health
Nattokinase may support health through a few mechanisms. It has potent fibrinolytic properties and
inhibit the growth and damaging effects of blood clots. Fibrin proteins help form blood clots to
promote healing at wound sites. However, excessive fibrin generation can cause clots to form and
(thrombosis). Nattokinase breaks down these blood clots by deactivating plasminogen activator
(PAI-1). Elevated PAI-1 levels are known risk factors for clot development and fat buildup in
Nattokinase may improve blood flow as well. One study noted nattokinase delayed thrombosis by
thromboxane from forming following oxidative damage to artery walls. The same study reported
blood flow. Nattokinase also exerts neuroprotective effects secondary to its ability to enhance
Multiple studies also reported that nattokinase exerts beneficial effects on blood pressure.
Potential Nattokinase Side Effects
Most individuals tolerate nattokinase well, and Japanese populations have consumed it for hundreds of
without experiencing significant adverse effects. However, individuals taking anticoagulants
should not take
nattokinase. Pairing blood-thinning agents increases the risk of a hemorrhage.
Tested by Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity,
and potency. To receive a copy of these test results or any other PureBulk supplement please
fill out the COA request form found here.