Niacin/L-Glutamine 1:1



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Supplement Facts & Directions

Supplement Facts

Serving Size: 600 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Niacin 300 mg 1512%
L-Glutamine 300 mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: None


Free of: Soy, Dairy, Yeast, Gluten & Additives.

Directions: As a dietary supplement, take 600 mg (3/16 tsp) daily with meals or as directed by a physician. An accurate gram weight scale is recommended.

Warning: If you are pregnant, nursing, taking any medications, or have any medical conditions consult your physician before use. Persons with liver or kidney disease or Reye's syndrome should not use it. Niacin may cause a temporary flushing reaction when serving more than 100 mg. Keep out of reach of children.

Product Details

What is Niacin (Vitamin B3)?

Niacin, more commonly known as vitamin B3, is an essential nutrient the body must obtain through dietary sources. It is crucial for several metabolic processes, including converting food into energy. It is a critical factor in synthesizing nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+). NAD+ and NADP+ are coenzymes that participate in numerous biochemical reactions essential for energy production, DNA repair, and cellular function. NADP+ is critical for cellular antioxidant defenses against free radicals and oxidative stress. Niacin deficiencies can cause brain fog and damage brain cells.

What is Glutamine?

Glutamine is a conditionally essential amino acid. Under normal circumstances, the body can produce enough glutamine to meet its needs. However, during certain conditions such as illness, stress, or intense physical activity, the body’s glutamine demand may exceed its ability to produce it. Individuals must obtain glutamine through dietary sources or supplements during these situations. Glutamine has several roles in the body. It supports muscle growth and repair, as the body uses it to synthesize proteins. Glutamine supports proper immune system function, particularly in cells that divide rapidly, such as immune cells. It can also serve as a cellular energy source and is a precursor to neurotransmitters that support cognitive health. Additionally, it is the precursor to the antioxidant glutathione and has anti-inflammatory properties.

Potential Niacin and Glutamine Benefits

Niacin and glutamine are notable antioxidants with complex interactions that synergistically enhance cognition and mental energy.

Niacin and Glutamine for Cognition and Concentration

Niacin and glutamine synergize to enhance cognition and concentration while alleviating brain fog and mental fatigue by working together to improve energy metabolism and cellular function. The body needs niacin and glutamine to synthesize NAD+. Niacin provides the essential precursor to form NAD+ and actively participates in the salvage pathway, while glutamine enhances the activity of the rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT) to facilitate efficient NAD+ production—even in situations where limitations might arise.

The following breaks down the intricate relationship between niacin, glutamine, and NAD+ synthesis:

  • Niacin's contribution: Niacin, specifically in the form of nicotinic acid, serves as a precursor for NAD+ synthesis. It helps convert nicotinic acid adenine dinucleotide (NAADP) to NAD+, a crucial step in the overall process. Additionally, niacin is a critical component in the salvage pathway, where it helps recycle nicotinamide (NAM) to regenerate NAD+. The brain prioritizes the salvage pathway for NAD+ synthesis because of its exceptional efficiency. It is the most effective mechanism that results in minimal NAD+ loss—less than 1%--thanks to proficient recycling processes.
  • Niacin and NAMPT: In the salvage pathway, the rate-limiting enzyme NAMPT acts as a catalyst to convert nicotinamide (a form of niacin) into nicotinamide mononucleotide (NMN). Converting nicotinamide into NMN is essential for subsequent NAD+ synthesis, and niacin availability influences the efficiency of this process.
  • Glutamine's role in NAMPT activity: Glutamine is a critical player in potentiating NAMPT activity. NAMPT is the enzyme responsible for converting nicotinamide to NMN, and glutamine enhances its effectiveness. NAMPT is the rate-limiting step in the salvage pathway, and glutamine's involvement helps overcome potential limitations in NAD+ production.
  • Glutamine's compensation mechanism: Glutamine also compensates for reduced carbon flow from glycolysis to the tricarboxylic acid (TCA) cycle, especially in the context of NAMPT inhibition. Glycolysis breaks down glucose to generate energy. The TCA cycle is another cellular process that further extracts energy from breakdown products. Carbon flow refers to the movement of carbon-containing molecules from glycolysis into the TCA cycle. Glutamine acts as an alternate carbon source when NAMPT inhibition disrupts the usual pathway for carbon flow. By doing so, glutamine ensures continued NAD+ synthesis efficiency, even under challenging conditions.

The intricate interplay between niacin and glutamine enhances overall cognitive function, concentration, and resilience against mental fatigue by optimizing NAD+ synthesis, energy metabolism, and cellular functions.

Niacin, Glutamine, and Glycine for Memory and Vigor

One study investigated how niacin, glutamine, and glycine affect memory and vigor. It found that niacin’s crucial role in NAD+ synthesis enhances memory and cellular energy production. The study also reported that glutamine synthesizes GABA and glutamate neurotransmitters that support brain function and communication between nerve cells. Meanwhile, glycine serves as a precursor to creatine, a compound that enhances energy metabolism and cognitive processes. Together, these components may activate the GH-IGF-I axis, with increased growth hormone potentially influencing cellular repair and metabolism. The synergy between these supplements could contribute to improved cognitive function, enhanced memory, and increased vigor by influencing various energy metabolism and neural communication pathways.

Potential Niacin and Glutamine Side Effects

Niacin is generally safe when used within recommended dietary levels. However, niacin can cause a temporary flushing or redness of the skin, particularly on the face and upper body. It is a common and usually harmless side effect. Individuals with diabetes should consult a physician before taking niacin, as it may affect blood sugar levels.

Most people tolerate glutamine supplements well. Some individuals may experience stomach cramps, bloating, gas, or diarrhea when taking glutamine supplements. Individuals with kidney problems should discuss glutamine supplements with their doctor. Glutamine can convert into glutamate, which can affect individuals with impaired kidney function.

References and Research

Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity, and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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