What is Niacinamide?
Niacinamide, also called nicotinamide, Vitamin B3 and/or nicotinic acid amide, is a water-soluble member of the family of B vitamins. There are two commonly used forms of Vitamin B3: niacin and niacinamide. The chemical difference between the two forms is that niacinamide has an amide group attached to the basic niacin form.
Both are readily absorbed from the small intestine but have different effects on the body. Both compounds can be converted into NAD and subsequently NADH, playing key roles in energy metabolism. In small amounts (less than 100 mg), niacin and niacinamide can be used interchangeably, however in larger amounts they do have different actions on the body. Niacin is important in the balance of good (HDL) and bad (LDL) cholesterol in the bloodstream. Niacinamide acts more to promote a healthy insulin response and to maintain joint health.
Niacin is one of the most stable of the B vitamins owing to the fact that it is resistant to the effects of heat, light, air, acid and alkali. Small amounts may be kept in the liver, while most of the excess is excreted in the urine.
Vitamin B3 or niacinamide works with vitamin B1, riboflavin (vitamin B2) , pyridoxine (vitamin B6), pantothenic acid, and biotin to break down and convert the carbohydrates, fats, and proteins in food into energy. The involvement of niacin, an essential B vitamin, in cellular energy production makes it important for healthy cardiovascular function, nervous system function and immune function.
Vitamin B3 is also helpful in the synthesis of hydrochloric acid, required for proper digestion. Additionally, vitamin B3 enhances the body's ability to eliminate toxins.
Niacinamide plays a key role in clearing the body of toxic and harmful chemicals. It also helps the body synthesize numerous sex and stress-related hormones in the adrenal glands and other parts of the body.
Vitamin B3 is needed for the action of many enzymes in the body. Enzymes are special substances that catalyze or speed up chemical reactions in the body. Those reactions include generating energy, breaking down dietary fats, creating certain hormones and cholesterol, processing genetic material (DNA), and the growth and maturation of cells.
Niacinamide is often used instead of niacin because it causes fewer side effects like flushing of the skin.
Niacin needs can be met partially by incorporating high protein foods in the diet. The body is able to convert tryptophan, an amino acid, into niacin. Niacinamide, or vitamin B3, works with other B vitamins to produce energy in the cells and to control circulation, hormones, glucose and hydrochloric acid in the body. Niacin also works with riboflavin (vitamin B2) and pyridoxine (vitamin B6) to maintain healthy skin and ensure the smooth operation of the nervous and digestive systems. Niacin is a vasodilator, meaning it makes blood vessels widen, which in turn leads to improved circulation.
Purity and Concentration of Niacinamide
This niacinamide USP powder is a pharmaceutical-grade form of vitamin B3 manufactured in strict compliance with United States Pharmacopeia standards (USP28). It contains no fillers, taste additives or anti-caking agents.
Potential Side Effects of Niacinamide
Niacinamide is safe at suggested serving sizes. Do not take oral niacinamide if you are currently taking anticonvulsant drugs such as carbamazepine or primidone. Consumption of large amounts of niacin can cause liver damage, peptic ulcers and skin rashes. Consult your prescribing physician if you are currently taking any anticonvulsant drug.
Check with your health professional before use.
Bioavailability, Mixing and Solubility of Niacinamide
This product dissolves quickly in water and has a sour taste that is only slightly bitter. Mix with water or juice and drink.
References & Further Research
University of Maryland Medical Center: Niacinamide
Medline: Niacin and niacinamide (Vitamin B3)
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