PureBulk, Inc.

Pregnenolone

$28.95
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Container: Bags
Size: 25 grams
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Supplement Facts

Serving Size: 100 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Pregnenolone 100 mg †

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive. Please call for exact numbers.

Other Ingredients: None

Contains:

Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.

Directions: As a dietary supplement, start with 10mg daily and increase to 100 mg (3/64 tsp) over a 1-2 week period as tolerated in the morning or as directed by a physician. An accurate gram weight scale is recommended.

Warning: NOT FOR USE BY INDIVIDUALS UNDER THE AGE OF 18 YEARS. Consult a physician before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased estrogen levels. Discontinue use and call a physician immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. Keep out of reach of children.

Tested By Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found  here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  • Supports hormone balance in men and women
  • Promotes memory, learning, and cognitive clarity
  • Helps to stabilize mood and reduce stress
  • May calm chronic, low-grade inflammation
  • Supports adrenal function and reduces fatigue
  • Declines naturally with age—supplementation helps maintain optimal levels

Pregnenolone vs DHEA

Pregnenolone sits at the top of the steroid pathway and converts into many hormones, including DHEA. DHEA lies further downstream, mainly supporting estrogen and testosterone production. Pregnenolone offers broader cognitive, stress, and hormonal benefits, while DHEA is more directly tied to energy, libido, and youthful hormone levels.

What is Pregnenolone?

Pregnenolone is a naturally occurring steroid hormone synthesized primarily in the adrenal glands, brain, and liver from cholesterol. Often referred to as the “mother hormone,” it serves as a precursor to a wide variety of other hormones, including progesterone, estrogen, testosterone, dehydroepiandrosterone (DHEA), and cortisol.

Beyond its role in hormone production, pregnenolone is considered a neurosteroid because it is synthesized in the brain and influences neurotransmission. Research shows that pregnenolone may modulate receptors involved in learning, memory, mood, and stress responses. Levels of pregnenolone naturally decline with age, which has led to interest in supplementation for supporting hormone balance and cognitive health.

Potential Pregnenolone Benefits

Pregnenolone for Men

For men, pregnenolone supplementation may help support healthy testosterone production indirectly by acting as a precursor in the hormonal pathway. It may also play a role in reducing age-related fatigue, supporting vitality, and maintaining cognitive clarity.

Pregnenolone for Women

In women, pregnenolone contributes to estrogen and progesterone synthesis. Supplementation may help support hormonal balance, particularly during perimenopause and menopause, when natural production of these hormones declines. Emerging evidence also suggests a role in supporting bone density and maintaining emotional balance.

Pregnenolone Supplements for Memory and Learning

As a neurosteroid, researchers have studied pregnenolone for its effects on memory consolidation and cognitive performance. Studies indicate it may enhance synaptic plasticity and modulate N-methyl-D-aspartate (NMDA) receptors, which are critical for learning and memory. Some studies show pregnenolone could be beneficial in age-related cognitive decline.

Pregnenolone Supplements for Mood and Stress

Pregnenolone interacts with GABA and NMDA receptors in the brain, both of which influence emotional regulation and stress response. Early research shows that pregnenolone supplementation may help alleviate nervousness, stabilize mood, and support resilience to everyday stressors.

Pregnenolone for Inflammation

Laboratory studies indicate pregnenolone has anti-inflammatory properties, potentially modulating microglial activity in the brain and influencing immune signaling pathways. These effects may help calm chronic, low-grade inflammation associated with aging and neurodegenerative conditions.

Pregnenolone Supplements for Fatigue

Because pregnenolone is a precursor to cortisol, the body’s primary stress hormone, supplementation may support healthy adrenal function and energy regulation. Some individuals report increased vitality, reduced fatigue, and greater resilience under stress when maintaining optimal pregnenolone levels.

Potential Pregnenolone Side Effects

Most individuals tolerate pregnenolone supplements well in appropriate serving sizes, but potential side effects may include:

  • Hormonal fluctuations (e.g., acne, irritability, or changes in menstrual cycle)
  • Sleep disturbances (especially when taken at night or in high amounts)
  • Mild headaches or digestive discomfort in sensitive individuals

Because pregnenolone affects hormone pathways, individuals with hormone-sensitive conditions (such as breast or prostate cancer), pregnant or nursing women, and those taking hormone-related medications should consult a healthcare professional before use.

References and Research

Solubility: Fat-soluble.

What to take with: Take pregnenolone supplements with a meal containing healthy fats (e.g., olive
oil, avocado, or nuts) to enhance absorption.

When to take: Take pregnenolone supplements in the morning to align with natural hormone rhythms and prevent sleep disturbances.

Spoon Set or Scale Needed?

Individuals should use a milligram scale to measure
pregnenolone supplement powder due to its small serving size.