Nerves are surrounded by an insulating fatty sheath comprised of a complex protein called myelin. B12 plays a vital role in the metabolism of fatty acids essential for the maintenance of myelin. Prolonged B12 deficiency can lead to nerve degeneration and irreversible neurological damage.
Those with vitamin B12 deficiency show irregular destruction of the myelin sheaths, which eventually causes paralysis and death. Vitamin B12 levels decrease with age and various measures of cognitive impairment are associated with reduced B12 status.
Vitamin B9 (folate) and vitamin B12 are critical to a process that clears homocysteine (Wikipedia) from the blood. Vitamins B12, B6, and B9 (folate) work closely together to control blood levels of homocysteine, an amino acid. Elevated plasma homocysteine concentrations are considered to be a risk factor for vascular disease and birth defects such as neural tube defects.
Purity and Concentration of Cyanocobalamin 1%
Purebulk's cyanocobalamin 1% powder contains no taste additives or anti-caking agents. Pure cyanocobalamin is mixed with 99% mannitol to produce the 1% concentration. Store in a cool, dry area protected from light. Reseal after each use.
This PureBulk product is manufactured in a cGmp certified and registered facility. PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found form.
Potential Side Effects of Cyanocobalamin
Vitamin B12 is considered safe and nontoxic in recommended serving sizes. However, cyanocobalamin can be toxic if taken in excess! Use extreme care when measuring!
What is vitamin B12 deficiency?
Vitamin B12 deficiency (Web MD) occurs when there is an abnormally low level of the vitamin absorbed in the body. It can be a factor in a variety of different health conditions and disorders. B12 deficiency inhibits the body’s ability to produce blood, increases blood cell destruction and is harmful to the nervous system. Characteristic signs of B12 deficiency include fatigue, weakness, nausea, constipation, flatulence, loss of appetite and weight loss. Symptoms of severe vitamin B12 deficiency (regardless of the cause) may include a burning feeling on the tongue, fatigue, weakness, loss of appetite, intermittent constipation and diarrhea, abdominal pain, weight loss, menstrual problems, psychological symptoms and nervous system problems such as numbness and tingling in the feet and hands.
Vitamin B12 absorption occurs in the small intestine and requires a secretion from the stomach known as gastric intrinsic factor. If intrinsic factor is deficient, absorption of vitamin B12 is severely diminished.
Vitamin B12 is not usually present in plant food sources, and it is likely that a vegetarian will not consume enough of this vitamin in their diet. Elderly people should also be aware of possible deficiency symptoms since cobalamin levels decline with age. Deficiencies in the elderly are usually caused by malabsorption of the vitamin. Symptoms of B12 deficiency may not show themselves for five to six years until the body's reserves are completely depleted and a supplement should be considered.
References & Further Research
National Institutes of Health, Office of Dietary Supplements: Vitamin B12
University of Maryland Medical Center: Vitamin B12 Overview
Linus Pauling Institute: Vitamin B12
The information at Purebulk.com is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.
The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits.
Tested by Accredited 3rd Party Labs
This PureBulk product is manufactured in a cGMP registered facility. PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.