What is Arginine?
L-arginine base powder is a free form of L-arginine, an amino acid that is a component in many proteins. It
is a central part of the urea cycle, a process that allows the body to dispose of excess ammonia. Arginine
is also the precursor to creatine, glutamate (the precursor to glutamine), and proline. Arginine is usually
a non-essential amino acid, as the body can synthesize it from citrulline. However, it can become
semi-essential while recovering from injuries or in individuals with kidney or intestinal disorders.
PureBulk derives this l-arginine base powder from glucose via molasses sugar. It is vegan- and
L-Arginine and the Urea Cycle
Ammonia is a toxic substance that the body must eliminate by converting it into glutamine via glutamate or
through the urea cycle. Arginine plays a key role regardless, as it’s a precursor to glutamate and actively
participates in the urea cycle.
Ammonia must first convert into carbamoyl phosphate before it can enter the cycle. The carbamoyl phosphate
then transfers a phosphate group to ornithine to convert into citrulline. From there, the citrulline
converts into argininosuccinate, which produces arginine when broken down. Arginase enzymes begin the last
step of the cycle by cleaving arginine to form ornithine and urea. The ornithine can then return to the
start of the cycle while the body excretes the urea through the urine.
Potential L-Arginine Benefits
Arginine as a Nitric Oxide Booster
The body uses arginine to make nitric oxide. Nitric oxide produces a vasodilation effect, which relaxes blood
vessels, widens arteries, and improves blood flow. Wider, more relaxed blood vessels may enhance exercise
performance and support heart health.
L-Arginine and L-Citrulline
Numerous scientific studies have examined l-arginine and l-citrulline’s roles as nitric oxide boosters. The
body can make nitric oxide by using citrulline to produce arginine. Unfortunately, nitric oxide has an
incredibly short half-life, which limits its ability to exert benefits. However, research shows that
citrulline and reduced glutathione synergize to sustain nitric oxide levels for longer.
Best Nitric Oxide Supplements
PureBulk carries numerous nitric oxide boosters. These include:
L-Arginine and Exercise Performance
Nitric oxide plays an important role in exercise. It helps deliver nutrients and oxygen to muscles during
intense exercise by improving blood flow. A clinical trial found that arginine supplements produced dramatic
increases in nitric oxide, allowing participants to exercise for much longer than the placebo group. Another
study examined arginine’s effects on athletes over a six-week period. The participants taking arginine
supplements performed significantly better than the placebo group.
Arginine and Heart Health
Improving nitric oxide goes beyond enhancing athletic performance. It can also support heart health by
improving circulation. It also helps to reduce pressure in blood vessels by relaxing them. Research also
shows that arginine helps reduce chest pain.
Arginine and Immune System Function
Arginine has several interactions with the immune system. It helps develop T-cells, a type of white blood
cell that protects the body from infections by attacking antigens directly. T-cells also direct the humoral
immune response to help B-cells eliminate invading pathogens by creating antibodies. Arginine also promotes
rapid lymphocyte production for faster wound healing.
Potential L-Arginine Side Effects
Research shows that doses up to 20g of arginine are likely safe; however, this far exceeds the recommended
600mg. Doses in excess of 10g may cause an upset stomach or diarrhea. Some individuals may experience mild
gastrointestinal side effects from standard doses, such as bloating, stomach pain, or nausea. Arginine may
interact with certain medications and medical conditions. Individuals with kidney or liver disease or those
taking blood pressure medication should consult a physician before taking arginine supplements. Individuals
recovering from a recent heart attack should not take arginine supplements.
Vegan l-arginine supplement has a slight ammonia smell when first opening the container. However, the odor
dissipates quickly. The product is not breaking down and is safe to consume.
Tested by Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity
and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.