What is N-Acetyl L-Glutamine?
N-acetyl L-glutamine is an acetylated analog and source of L-glutamine. L-glutamine, or simply glutamine, is the most abundant amino acid that serves several roles in the human body. It acts as an energy source for the digestive and immune systems, which prefer glutamine over glucose. It’s also a popular pre-workout supplement as it synthesizes proteins, supports exercise performance, and reduces muscle soreness. Whey protein, casein, meat, and eggs are the best food sources of glutamine, but taking supplements provides more reliable results.
Glutamine is not an essential amino acid, as the body can synthesize it from glutamate and ammonia. However, it can become conditionally essential during periods of stress because the body’s glutamine demands exceed its production capabilities. Example scenarios include intense exercise or recovering from injuries, surgeries, and illnesses. Vegans and vegetarians may need glutamine supplements, as the richest food sources come from animal products. Regardless of how a glutamine deficiency occurs, the body will break down muscle to obtain glutamine if necessary.
Potential N-Acetyl L-Glutamine Benefits
N-Acetyl L-Glutamine for Exercise Performance and Muscle Soreness
Glutamine supplements like N-acetyl L-glutamine are popular among athletes and fitness enthusiasts. Research shows that athletes recover from intense workouts faster and experience less muscle soreness after exercising when taking glutamine supplements. Studies also note that glutamine can reduce aerobic exercise-induced inflammation. Less inflammation and muscle soreness combined with a faster exercise recovery period may enhance exercise performance by allowing individuals to exercise harder and more often.
N-Acetyl L-Glutamine for Weight Loss and Body Composition
Glutamine supplements may support weight loss efforts by improving glycemic control and reducing sugar cravings. Research also shows that glutamine helps overweight individuals reduce their waist circumference and significantly decrease their fat-free mass for a better body composition. Animal research also reports that glutamine attenuates weight gain and high blood sugar even when consuming a high-fat diet.
N-Acetyl L-Glutamine as an Antioxidant and Anti-Inflammatory
Glutamine has significant antioxidant and anti-inflammatory properties that may benefit heart health and kidney health. It also exerts antioxidant effects following intense exercise. Several studies note that glutamine effectively reduces oxidative stress and inflammatory markers. It also lowers glycation markers that cause advanced glycation end products (AGEs) to form. Too many AGEs in the body can cause oxidative stress, inflammation, heart health problems, and premature aging.
Research also shows that glutamine produces significant increases in other antioxidants, such as superoxide dismutase (SOD) and reduced glutathione (GSH). Glutathione is one of the most protective antioxidants found in the human body, and many regard it as the master antioxidant. It improves how well the body uses and recycles other antioxidants, including alpha-lipoic acid, coenzyme Q10 (CoQ10), and vitamins C and E.
N-Acetyl L-Glutamine for Gut Health
The gut relies on the gastrointestinal epithelium to act as a barrier against pathogens, toxins, allergens, and more. Disrupting the gut barrier can cause mucosal inflammation and contribute to the formation of gastrointestinal diseases. Glutamine is critical to maintain mucosal integrity and the gut barrier’s functionality. Catabolic stressors, such as injuries or recovering from surgery, cause the bowels to consume more glutamine than the body can produce, hence its conditionally essential status. Without adequate glutamine, the gut can’t function properly and is prone to perforation.
N-Acetyl L-Glutamine and the Immune System
Leukocytes, a type of white blood cell, give preference to glutamine over glucose as an energy source as it supplies energy more rapidly. However, leukocytes can’t synthesize glutamine and must rely on dietary sources for their primary fuel. Without adequate glutamine, leukocytes can’t defend against infectious invaders as well and may compromise the immune system.
Potential N-Acetyl L-Glutamine Side Effects
As an analog of the naturally occurring amino acid glutamine, n-acetyl l-glutamine supplements are unlikely to cause side effects. Mild side effects may occur in some individuals, such as dizziness, heartburn, stomachache, bloating, or nausea. Individuals with liver conditions should speak with a doctor before taking n-acetyl l-glutamine supplements.
Tested by Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.