REPRESENTATIVE DOCUMENTS
COA
*(Documents above may vary from batch received. Click here to request batch-specific documents)
| Amount Per Serving | % Daily Value* |
|---|---|
| Glucosamine Hydrochloride (from D-Glucosamine HCl) 1000 mg | † |
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡
These supplement facts may vary from the product you receive. Please call for exact numbers.
Contains: Shellfish
Free of: Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.
Directions: As a dietary supplement, take 1000 mg (1/4 tsp) up to three times daily, or as directed by a physician.
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Diabetics, or persons with asthma or shellfish allergies should not take this product. Keep out of reach of children.
Glucosamine HCl is glucosamine combined with hydrochloride salt. Hydrochloride salt improves the glucosamine’s stability and increases its bioavailability to 99% purity. Glucosamine is a simple amino sugar that molecules use for fuel. It also serves as the foundational component for all carbohydrates. Glucosamine plays a pivotal role in protecting joints. It is a component of the glycosaminoglycans and proteoglycans that the cartilage matrix uses to cushion bone ends. Glucosamine also helps reduce joint friction. Glucosamine amides bond with glucuronic acid to form hyaluronic acid. Hyaluronic acid is one of the primary compounds found in the synovial fluid that lubricates joints. It also preserves joint integrity by enhancing synovial fluid viscosity, reducing inflammation, and protecting the cartilage matrix.
Glucosamine occurs naturally in the shells of shellfish. Manufacturers obtain the supplement by processing chitin from various crustaceans, including crabs, lobsters, and shrimp. PureBulk also carries a vegan glucosamine supplement derived from non-genetically modified (non-GMO) corn. Vegan glucosamine supplements are a good alternative for vegans, vegetarians, and individuals with shellfish allergies or sensitivities.
Glucosamine is a popular supplement to support joint health by improving joint function and reducing joint pain. It’s a precursor to numerous connective tissue compounds that support cartilage and bone health, including glycoproteins and glycosaminoglycans. It also increases the production of cartilage building blocks like proteoglycans. Glucosamine helps synthesize synovial fluid, too. Joints use this fluid for shock absorption, reducing friction, and eliminating metabolic waste from cartilage tissues. It also inhibits cartilage breakdown and boosts cartilage healing rates, which improve joint mobility and reduce joint pain. Glucosamine has anti-inflammatory properties, too. It represses inflammatory pathway signaling and reduces inflammation markers in synovial cells.
Athletes and fitness enthusiasts may benefit from taking glucosamine supplements. Joint integrity declines with age, but intense exercise can also cause cartilage breakdown. A clinical study observed the effects of glucosamine supplements on professional and collegiate athletes. Researchers compared the athletes’ collagen breakdown and synthesis rates to non-athletes before starting the trial. They noted that athletes degraded their collagen much faster than non-athletes; however, both groups had similar synthesis rates. They concluded that athletes wear out their joints much faster than non-athletes, but their collagen doesn’t recover any quicker. Researchers gave the athletes glucosamine supplements daily for three months. When the trial concluded, the athletes had dramatic reductions in collagen breakdown while maintaining their collagen synthesis rates.
Glucosamine synergizes with several other supplements for joint health. These include chondroitin, methylsulfonylmethane (MSM), and hyaluronic acid.
Glucosamine and chondroitin are both GAGs with pain-relieving properties. They calm overexcited pathways that aggravate joint pain and help reduce inflammation. Glucosamine and chondroitin slow collagen breakdown while encouraging collagen synthesis when taken together.
Methylsulfonylmethane (MSM) is a sulfuric compound purported to support joint health. Collagen and cartilage synthesis rely on sulfur, and MSM is 34% sulfur. A 12-week study reported that glucosamine synergized with MSM. The combination reduced joint swelling better than either supplement did individually. Another 12-week study reported the synergy of glucosamine, chondroitin, and MSM. The blend reduced knee pain more effectively than a combination of glucosamine and chondroitin.
Hyaluronic acid is another GAG that lubricates joints and connective tissues. Glucosamine is essential to synthesize hyaluronic acid. Taking glucosamine supplements may boost hyaluronic acid levels. Research indicates that hyaluronic acid also synthesizes with glucosamine and chondroitin to yield better improvements in joint pain.
Glucosamine side effects are uncommon. Some individuals may experience mild side effects, such as gassiness, constipation, diarrhea, or headaches. Individuals taking the anticoagulant warfarin should consult their physician before taking glucosamine supplements, as it can amplify its effects. Individuals with type II diabetes should also discuss glucosamine supplements with their doctor, as they can sometimes have a slight hypoglycemic effect. Individuals with a high risk of developing glaucoma should not take glucosamine.
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.