REPRESENTATIVE DOCUMENTS
COA
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Supplement Facts & Directions
Supplement Facts
Serving Size: 1000 milligramsServings Per Container: Varies
Amount Per Serving | % Daily Value* |
---|---|
D-Glucosamine Sulfate •2KCI 1000 mg | † |
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡
These supplement facts may vary from the product you receive. Please call for exact numbers.
Other Ingredients: None
Contains: Shellfish
Free of: Added Sugar, Soy, Dairy, Yeast, Gluten, Corn & Additives.
Directions: As a dietary supplement, take 1000 mg (1/4 tsp) up to three times daily or as directed by a physician.
Warning: If you are pregnant, nursing, taking any medications, or have any medical conditions consult your physician before use. Too much potassium is toxic, even fatal. DO NOT exceed the suggested amount. People with diabetes, asthma or shellfish allergies should not take this product. Keep out of reach of children.
Product Details
What is Glucosamine Sulfate 2KCl?
Glucosamine sulfate 2KCl is glucosamine sulfate bonded with potassium salt to improve its stability. Glucosamine is a monosaccharide—the simplest form of sugar that the body needs for fuel and as building blocks for carbohydrates and nucleic acid. Glucosamine may support joint health through several mechanisms. It’s a component of the cartilage matrix that protects the ends of bones and reduces friction between joints. It’s also a component of hyaluronic acid (HA). HA is found in the synovial fluid that lubricates joints.
D-Glucosamine Sulfate Potassium comes from shellfish. However, PureBulk also carries a vegetarian- and vegan-friendly glucosamine supplement. It’s also a good alternative source of glucosamine for individuals with shellfish allergies.
Potential Glucosamine Benefits
Glucosamine for Joints
Glucosamine is a popular joint health supplement that may improve joint function, mobility, and pain. The body uses it to make glycolipids, proteoglycans, and glycosaminoglycans (GAGs) to support healthy cartilage and bones. Glucosamine also boosts synovial fluid production, which is essential for joint lubrication, shock absorption, and waste removal from the cartilage. Glucosamine supplements may improve joint mobility and reduce joint pain by preventing cartilage breakdown and enhancing the rate of cartilage repair. Glucosamine may also act as an anti-inflammatory in joints, as it blocks the signals from inflammatory pathways and effectively lowers inflammation biomarkers.
Glucosamine isn’t only for age-related joint pain. Athletes put their joints through significant strain and may benefit from glucosamine supplements. One study examined the effects of glucosamine on professional and collegiate-level athletes. Researchers noted that the athletes had much more collagen breakdown compared to the control group. However, both groups had the same rate of collagen regeneration, meaning athletes wear down their joints much more rapidly but aren’t repairing than any faster. After three months of daily glucosamine supplements, the athletes saw a significant decrease in collagen breakdown without compromising collagen production.
Potential Potassium Benefits
The potassium content in glucosamine sulfate 2KCl may enhance joint and bone health. The body needs potassium to maintain bone strength and bone mineral density. Several studies have noted that individuals consuming high-potassium diets have a lower risk of developing weak and brittle bones. Potassium also has anti-inflammatory properties, and multiple studies found it exerts a pain-relieving effect on joints.
Other Supplements for Joint Health
Glucosamine synergizes with several other supplements for joint health. These include:
- Glucosamine and Chondroitin. Chondroitin is another glycosaminoglycans (GAG) that may provide joint pain relief. Numerous studies have reported that taking glucosamine and chondroitin together enhances collagen production and reduces its breakdown.
- Glucosamine and MSM. The body needs sulfur for numerous functions, including collagen and cartilage synthesis. Methylsulfonylmethane (MSM) is a rich sulfur source and may improve those processes. It also has anti-inflammatory properties and synergizes with the hyaluronic acid (HA) found in the synovial fluid to provide even greater anti-inflammatory effects. Research also shows that taking glucosamine and MSM improves swollen joints better than when taking either supplement by itself.
- Hyaluronic acid (HA). HA is also a GAG and plays a pivotal role in lubricating joints and connective tissues, reducing friction between joints, and protecting against cartilage breakdown. Glucosamine supplements may help increase HA levels. HA also shows synergy with glucosamine and chondroitin and may enhance each other’s effects on joint health.
Glucosamine, Chondroitin, and MSM
Just because supplements share similar properties doesn’t always mean they’ll synergize. However, researchers found that glucosamine, chondroitin, and MSM produced greater improvements in knee pain over the course of three months than a combination of only glucosamine and chondroitin.Potential Glucosamine Sulfate 2KCL Powder Side Effects
Most individuals tolerate glucosamine well. It may cause mild side effects, such as headache, gas, diarrhea, or constipation. Individuals with an increased risk of developing glaucoma should not take glucosamine supplements. Glucosamine may affect blood sugar levels, so individuals with diabetes should consult a physician before taking glucosamine supplements. Glucose may interact with warfarin and increase the risk of bleeding.
References
- https://pubmed.ncbi.nlm.nih.gov/20649060/
- https://pubchem.ncbi.nlm.nih.gov/compound/D-glucosamine
- http://www.sciencedirect.com/science/article/pii/B9780323241458000028
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686334/
- http://www.rsc.org/Education/Teachers/Resources/cfb/Carbohydrates.htm
- https://www.worldcat.org/oclc/30894482
- https://www.sciencedirect.com/topics/chemistry/hyaluronic-acid
- https://www.nccih.nih.gov/health/glucosamine-and-chondroitin-for-osteoarthritis
- https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/glucosamine
- https://pubmed.ncbi.nlm.nih.gov/24989639
- http://www.orthopaedicsone.com/display/Main/Synovial%20fluid
- https://pubmed.ncbi.nlm.nih.gov/25719429/
- https://www.sciencedirect.com/science/article/pii/B9780323244855002825
- https://www.sciencedirect.com/topics/immunology-and-microbiology/connective-tissue
- https://www.worldcat.org/oclc/850877694
- https://pubmed.ncbi.nlm.nih.gov/28586015/
- https://pubmed.ncbi.nlm.nih.gov/27422331/
- https://pubmed.ncbi.nlm.nih.gov/30940583/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553787
- https://www.ncbi.nlm.nih.gov/books/NBK544295/
- https://www.ncbi.nlm.nih.gov/pubmed/22970568
- https://www.ncbi.nlm.nih.gov/pubmed/23107559
- https://www.ncbi.nlm.nih.gov/pubmed/12405691
- https://www.sulphurinstitute.org/pub/?id=8c64bf34-bc30-5bd9-0719-f6de83f7e841
- https://www.sciencedirect.com/topics/medicine-and-dentistry/sulfur
- https://www.ncbi.nlm.nih.gov/pubmed/17516722
- https://www.ncbi.nlm.nih.gov/pubmed/11896744
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372953/
- https://www.mdpi.com/1422-0067/21/21/7956/htm
- https://www.ncbi.nlm.nih.gov/pubmed/17549239
- https://www.ncbi.nlm.nih.gov/pubmed/11127660
- https://pubmed.ncbi.nlm.nih.gov/21964857
- https://www.oarsijournal.com/article/S1063-4584(14)00951-0/fulltext
- https://www.researchgate.net/profile/Aldo-Marsetio/publication/322833040_Comparison_of_Glucosamine-Chondroitin_Sulfate_with_and_without_Methylsulfonylmethane_in_Grade_I-II_Knee_Osteoarthritis_A_Double_Blind_Randomized_Controlled_Trial/links/5caf5ae6299bf120975e30aa/Comparison-of-Glucosamine-Chondroitin-Sulfate-with-and-without-Methylsulfonylmethane-in-Grade-I-II-Knee-Osteoarthritis-A-Double-Blind-Randomized-Controlled-Trial.pdf
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1148875
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997142/
- https://academic.oup.com/jcem/article/98/1/207/2823184
- http://www.rheumres.org/article_48075.html
- http://www.jpain.org/article/S1526-5900(08)00497-5/abstract
Tested by Accredited 3rd Party Labs
PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.
*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.