Methylsulfonylmethane (MSM)


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Supplement Facts & Directions

Supplement Facts

Serving Size: 1500 milligrams
Servings Per Container: Varies
Amount Per Serving % Daily Value*
Methylsulfonylmethane 1500mg

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value Not Established
‡ These supplement facts may vary from the product you receive.    Please call for exact numbers.

Other Ingredients: None


Free of:  Sugar, Soy, Dairy, Yeast, Gluten, Corn, & Additives.

Directions:  As a dietary supplement, take 1500 mg (level unpacked 3/8 tsp) up to three times daily, or as directed by a physician.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children. Store in a cool, dark & dry place.

Product Details

What is Methylsulfonylmethane (MSM)?

Methylsulfonylmethane, or MSM, is a naturally occurring sulfur compound found in the body and in green vegetables, milk, fish and grains. It is marketed as a dietary supplement and sold as a chemical compound derived from dimethyl sulfoxide (DMSO).

Methylsulfonylmethane is in the fluid and tissues of all living organisms and in many animal foods. It is known by several names, including sulfonyl sulfur, DMSO2 and methyl sulfone. In its purified form, MSM can be described as an odorless, tasteless, white, water-soluble crystalline solid.

Sulfur is needed for the structure of every cell in the body. Hormones, enzymes, antibodies and antioxidants all depend on it. Because the body uses sulfur on a regular basis, it must be replenished for optimal nutrition.

Although MSM is found in the normal human diet, it can be destroyed as foods are processed. It is no longer present in foods that have been stored during shipping or held in storage. And since it bonds with moisture, MSM is lost when dehydration occurs.

Like Glucosamine and Chondroitin, MSM provides raw materials the body needs.

MSM is organic, nontoxic and nonmetallic. It's an analog of the compound dimethysulfoxide and 34 percent elemental sulfur by weight, making it a rich source of sulfur.

As one of the most abundant elements in all living organisms, sulfur is found in more than 150 types of bodily compounds, from enzymes and tissues to hormones and antioxidants. It's also a component of structural protein found in hair, skin, and joints.

Sulfur occurs in connective tissue and is in a key structural component known as collagen, which helps form cartilage.

MSM is often referred to as a penetrant because it can make the walls of cells more permeable, making it easier to get rid of toxins and absorb nutrients.

Purity and Concentration of Methylsulfonylmethane (MSM)

This pharmaceutical-grade methylsulfonylmethane (MSM) powder contains no fillers, taste additives or anti-caking agents.

Potential Side Effects of Methylsulfonylmethane (MSM)

MSM is rated as one of the least toxic substances in biology and medicine, comparable to water. There have been over 30 years worth of research studies done at the Oregon Health Science University in Portland, Oregon, as well as numerous other research facilities. Inert by nature, it is non-allergenic, non-pyretic and does not interfere with pharmacological effects. As such, no side effects have been reported with the use of MSM. It should be noted however, that MSM may have a mild blood-thinning effect. Persons taking blood-thinning medication, should consult with their doctor before using MSM as a nutritional supplement. Also, though generally a desired effect, MSM may cause hair and fingernails to grow at a faster rate.

Bioavailability, Mixing and Solubility of Methylsulfonylmethane (MSM)

This product dissolves quickly in water and has a slightly bitter but not unpleasant taste. Mix with water or citrus juice. If you prefer, Purebulk offers MSM capsules

How should I store it?

Store it in a cool, dry, dark location. Reseal tightly between uses.

References & Further Research

WebMD: Methylsulfonylmethane

University of Maryland Medical Center: Sulfur

The information at is NOT a substitute for medical advice. ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

The U.S. Food and Drug Administration (FDA) regulates herbal and other dietary supplements differently than conventional medicines. The standards for supplements are found in the Dietary Supplement Health and Education Act (DSHEA), a federal law that defines dietary supplements and sets product-labeling standards and health claim limits.

Tested by Accredited 3rd Party Labs

PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here.

*NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.