What is Cissus Quadrangularis?
Cissus quadrangularis is a plant that belongs to the grape family. It has many names, including veldt grape,
adamant creeper, winged treebine, and devil’s backbone. It is often considered an ayurvedic supplement, but
it grows in many locations was a frequent feature in several folk remedies. Ayurvedic cultures used cissus
quadrangularis to mend broken bones and injured tendons and ligaments. Indian cultures used cissus
quadrangularis as a Siddha remedy for pain relief and healing broken bones. It earned the name
asthisamharaka, meaning that which prevents the destruction of bones, and hadjod. Several
other cultures relied on cissus quadrangularis for bone fractures, including the Assamese and Garo people of
Meghalaya and Bangladesh.
It is a potent antioxidant that may support joint health, enhance exercise recovery, and support healthy
Potential Cissus Quadrangularis Benefits
Cissus Quadrangularis Antioxidants
Free radicals are a normal part of numerous biological processes, but they cause oxidative stress when they
outnumber antioxidants. That stress results in oxidative damage that worsens or promotes the development of
many chronic illnesses and induces premature aging. Cissus quadrangularis is rich in antioxidant compounds,
including ascorbic acid (vitamin C), carotenoids, phenols, resveratrol, quercetin, and vitamin E. It exerts
powerful antioxidant effects by scavenging free radicals and inhibiting free radical and lipid peroxide
production. Research shows it also effectively reverses the damaging effects of free radicals by increasing
Cissus Quadrangularis Supplements for Joint Support
Cissus quadrangularis has a long history as a supplement for joint support. Modern research confirms that
cissus promotes bone health in several ways. One study found that cissus quadrangularis expedited bone
fracture recovery. A larger study lasting three months noted that cissus quadrangularis fostered better bone
fracture healing by increasing the proteins the body needs to form bones.
Other clinical trials examined cissus quadrangularis’ effects on joint pain and swelling. Research shows that
cissus quadrangularis reduces the swelling and pain caused by fractured bones. It has also proven effective
at reducing chronic joint pain and swelling in animal studies. Researchers believe this is because cissus
quadrangularis decreases numerous inflammation markers.
Best Supplements for Joints
PureBulk carries numerous supplements for joint health. These include:
Cissus Quadrangularis and Weight Loss
Cissus quadrangularis has several effects that support fat loss and weight loss efforts. Researchers believe
cissus helps achieve weight loss by suppressing appetite, reducing food consumption, and interacting with
enzymes that digest fats and sugar. Cissus synergizes with several other supplements to induce weight loss
and fat loss while also reducing waist circumference, total cholesterol, and LDL cholesterol.
One study found that participants taking a formula containing cissus quadrangularis, green tea extract with
caffeine, and other vitamins experienced a decrease in weight and belly fat, regardless of their diets. The
cissus quadrangularis blend also improved participants’ total cholesterol, LDL (bad) cholesterol, and
Another study reported that cissus quadrangularis synergizes with African mango extract to significantly
improve fat loss and weight loss compared to a placebo. Participants taking cissus quadrangularis with
African mango extract lost 4kg of body weight, whereas the placebo group did not experience any weight loss.
By the end of the 10-week trial, the cissus quadrangularis and African mango group lost nearly 12kg of body
weight and just over 20% of their starting body fat.
Cissus Quadrangularis for Exercise Recovery
Strenuous or high-impact exercise puts a lot of stress on joints. Cissus may improve recovery after workouts
by reducing exercise-induced joint pain and inflammation. One eight-week study reported that
exercise-trained men taking cissus quadrangularis experienced a 31% reduction in joint pain and impairment.
Potential Cissus Quadrangularis Side Effects
Most individuals tolerate cissus quadrangularis supplements well. Some may experience mild side effects, such
as dry mouth, gas, headache, sleep disruption, or diarrhea. Individuals taking diabetes medication should
consult a physician before taking cissus quadrangularis extract, as it may lower blood sugar levels.