What is DL-Methionine?
DL-methionine is a combination of the biologically active L-methionine and its optical isomer, D-methionine.
D-methionine is not proteogenic, unlike L-methionine; however, DL-methionine is less expensive to
manufacture than isometrically pure L-methionine.
L-methionine is an essential amino acid and a main component in structural proteins. It contains sulfur and
serves as a methyl donor in biochemical reactions. Methionine is an intermediate in the biosynthesis of
L-cysteine, L-carnitine, taurine, lecithin, phosphatidylcholine, and other
phospholipids, as well as the
enzymatic cosubstrate S-adenosyl methionine (SAMe). Because
L-methionine is an essential amino acid, it is
not synthesized in the human body and must be supplied by dietary intake or supplementation.
L-methionine supplements, such as DL-methionine, are necessary for supporting healthy metabolic, central
nervous, and immune system functions. As a proteinogenic amino acid, L-methionine plays a role in protein
synthesis, which is essential for repairing muscles after vigorous workouts. Methionine is also a critical
sulfur source for DNA synthesis and for cells to function properly. The food and beverage industry uses
DL-methionine as a nutritional supplement to provide dietary methionine, a flavoring agent, and to enrich
Potential DL-Methionine Benefits
Methionine is a highly versatile amino acid that supports numerous bodily functions. It helps synthesize
numerous amino acids, amino acid derivatives, and essential fats and converts easily into
s-adenosylmethionine (SAMe). SAMe plays a role in energy
production as it can synthesize creatine. The body
needs creatine to replenish the phosphate group on adenosine triphosphate (ATP), which it then uses to power
cellular processes. SAMe is also a methyl donor for protein molecules and DNA.
Methionine and Antioxidants
Methionine supports the body’s antioxidant activity by producing cysteine, which converts into taurine and
glutathione. Glutathione is an essential
antioxidant that bolsters the immune system to fight off invading
pathogens and toxins. It also increases the availability of other antioxidants and protects the body against
oxidative stress, which directly reduces oxidative damage.
Methionine and Detoxification
Methionine contains sulfur, which the body requires for many of its detox processes and provides protection
against pollutants. Methionine also positively influences selenium and zinc absorption and uptake, both of
which synergize for enhanced DNA protection and repair. Methionine also binds to and chelates heavy metals,
making it easier for the body to excrete them. It’s also effective for attenuating copper toxicity and is an
antidote to acetaminophen poisoning. Additionally, it plays a lipotropic role by inhibiting fat buildup in
Methionine for Hair, Skin, and Nails
Sulfur is an essential component for healthy hair, skin, and nails. Sulfur-containing compounds like
methionine may produce better skin tone, more pliable hair, and stronger nails. Sulfur compounds also help
regulate ammonia, which stimulates hair growth. Additionally, the keratin proteins in the hair are rich in
sulfur and are critical for hair strength and elasticity.
Potential DL-Methionine Side Effects
Standard DL-methionine doses don’t typically produce significant side effects. However, individuals may
experience headaches, nausea, or vomiting with high doses. Extreme doses can result in more dangerous health
effects, such as elevated white blood cell count, increased calcium excretion, and altered levels of
potassium and pH in the blood. B vitamin deficiencies, particularly vitamin B12, may cause an increase in
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