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Nicotinamide mononucleotide (NMN). NMN is a precursor to NAD+ and promotes healthy aging in several ways. NMN enhances cellular energy production, reduces oxidative stress, and improves cellular resilience against age-related decline by supporting mitochondrial function. It also activates SIRT1 sirtuin proteins known for their anti-aging effects. SIRT1 proteins regulate cellular processes related to longevity, DNA repair, and stress response. Additionally, NMN supplements improve metabolic function, enhance cognitive performance, and increase lifespan in animal models. [1 - 8]
Resveratrol. Resveratrol is a polyphenol found in grapes and red wine that also promotes healthy aging by activating SIRT1 sirtuin proteins. Activating SIRT1 reduces the risk of age-related illnesses by enhancing mitochondrial function, DNA repair mechanisms, and cellular stress resistance. Resveratrol also supports healthy aging by reducing oxidative stress and relieving inflammatory reactions. Like NMN, research shows that resveratrol increases lifespan in animals. PureBulk carries Trans-Resveratrol Powder Pure and Trans-Resveratrol Powder 50%. [9 - 13]
Pterostilbene. Pterostilbene is a resveratrol derivative found in blueberries and grapes. It is a stilbenoid compound with a greater potency and oral bioavailability than resveratrol. Pterostilbene is rich in antioxidants that scavenge free radicals and boost other antioxidants, such as superoxide dismutase (SOD). It supports healthy aging by activating sirtuin proteins and enhancing cellular resilience. It protects against age-related illnesses and promotes longevity by reducing inflammation, oxidative stress, and DNA damage. [14 - 18]
Curcumin. Curcumin, a polyphenol compound found in turmeric, promotes healthy aging and longevity by activating sirtuin proteins, particularly SIRT1. Activating SIRT1 triggers cellular pathways that reduce factors known to promote age-related diseases, such as inflammation, oxidative stress, and DNA damage. SIRT1 proteins also delay cellular senescence, a process that occurs when cells stop dividing. Senescent cells expedite aging and disease progression as they accumulate. Additionally, curcumin inhibits proteins that promote aging, such as mTOR and NF-kB. PureBulk carries Curcumin 95% Natural Turmeric Extract and Curcumin 95% Natural Turmeric Extract Softgels. [19 - 22]
Fish oil. Fish oil supplements are rich in omega-3 fatty acids EPA and DHA that promote healthy aging through a few mechanisms. They reduce inflammation, which can help mitigate the chronic low-grade inflammation associated with aging and age-related diseases. EPA and DHA also support cardiovascular health by reducing triglyceride levels, improving blood vessel function, and lowering vascular pressure, thus reducing the risk of developing age-related cardiovascular diseases. Essential fatty acids enhance brain function, too, by supporting neuronal structure, neurotransmitter function, and cognitive performance. [23 - 33]
Green tea extract (EGCG). Green tea extract is rich in epigallocatechin gallate (EGCG) catechins that promote healthy aging by activating sirtuin proteins, boosting antioxidant defenses, and reducing inflammation. Once activated, sirtuin proteins can enhance mitochondrial function, DNA repair, and cellular stress resistance. Reducing oxidative stress and inflammation is also essential for healthy aging. Like curcumin, EGCG can delay cellular senescence by modulating signaling pathways that regulate cell growth. Animal studies also show that EGCG can extend lifespan. [19, 34 - 39]
Coenzyme Q10 (CoQ10). CoQ10 promotes healthy aging by supporting mitochondrial function, cellular energy production, and antioxidant defenses. CoQ10 is crucial for cellular energy production, as it is a cofactor in the electron transport chain that generates ATP, the energy currency of cells. CoQ10 also has potent antioxidant properties. It scavenges free radicals and reduces oxidative damage to cells and tissues. CoQ10 can reduce the risk of developing age-related cognitive decline and cardiovascular issues, too. [40 - 45]
Fisetin. Fisetin is a flavonoid compound found in fruits and vegetables that promotes healthy aging by activating sirtuin proteins and enhancing antioxidant defenses. It contributes to longevity and improved healthspan by reducing inflammation, protecting against DNA damage, and supporting cellular stress resistance. Fisetin's neuroprotective effects also benefit cognitive function and brain health with age. [46 - 54]
Probiotics. Probiotics support healthy aging by maintaining a balanced gut microbiome, which is essential for immune function, digestive health, and nutrient absorption. They enhance longevity by reducing inflammation, boosting gut barrier function, and improving metabolic regulation. Research also shows that probiotics support healthy brain function with age. PureBulk carries numerous prebiotic supplements that nourish gut probiotics, including Turkey Tail Mushroom Extract, Fructo-oligosaccharide (FOS) Powder, Psyllium Husk Powder, D-Mannose Powder, and Lactose. PureBulk also supplies White Kidney Bean Extract, which acts like probiotics in the gut. [55 - 60]
Bacopa monnieri. Bacopa monnieri is an adaptogenic herb that improves the body's resilience to physical and mental stress. It promotes healthy aging by reducing stress, supporting cognitive function, and enhancing brain health. It also supports longevity by improving neurotransmitter activity, reducing oxidative stress, and protecting against age-related cognitive decline. It exerts anti-aging effects on the brain by reducing age-related neural inflammation. [61 - 67]
Reishi mushroom extract. Reishi mushroom extract is an adaptogen that promotes healthy aging by supporting immune function, reducing inflammation, and enhancing vitality. Its bioactive polysaccharides, triterpenes, and sterols enhance longevity by modulating immune responses, improving stress resilience, and protecting against age-related diseases. [68 - 71]
Ashwagandha. Ashwagandha is an adaptogenic herb rich in bioactive withanolides that exert anti-stress, anti-inflammatory, and neuroprotective effects. It promotes longevity by modulating stress response pathways and enhancing cellular resilience. It activates sirtuin proteins like SIRT1 and stimulates antioxidant enzymes to reduce cellular damage caused by oxidative stress and inflammation. Ashwagandha's neuroprotective effects also support cognitive function and brain health, contributing to healthy aging and improved quality of life. [72 - 76]
Leucine. Leucine is an essential amino acid and one of three branched-chain amino acids (BCAAs). It activates SIRT1 proteins, a pro-longevity mechanism also utilized by resveratrol, to support healthy aging. Milk proteins are the best leucine source among animal proteins, and researchers believe these dairy proteins owe their health benefits to leucine. For example, one study found that consuming a dairy-rich diet increased fat cell SIRT1 activity in fat cells by 13% and in muscle tissues by 43%. Additionally, leucine stimulates mitochondrial biogenesis, a process that enhances mitochondrial function and reduces mitochondrial dysfunction damage—a significant hallmark of aging. [77 - 81]
Collagen. Collagen is an essential structural protein for skin health, joint function, and connective tissue integrity. Unfortunately, collagen production decreases sharply with age. Supplementing with collagen supports healthy aging by improving skin elasticity, joint flexibility, and bone density. It helps maintain mobility and quality of life by promoting tissue repair, reducing inflammation, and supporting overall musculoskeletal health. PureBulk carries Bovine, Chicken, and Fish Hydrolyzed Collagen Powder. [82 - 89]
Marigold flower extract (zeaxanthin). Zeaxanthin is a carotenoid antioxidant found in marigold flowers. It promotes healthy aging by protecting against oxidative stress and supporting eye health. Zeaxanthin protects the retina and eye lens from age-related decline and can reduce the risk of age-related macular degeneration. Preserving macular health is crucial for maintaining eyesight and ensuring a higher quality of life as people age, allowing them to enjoy clear and sharp vision for everyday activities. [90 - 96]
Calcium. Calcium promotes healthy aging by supporting bone health and muscle function. It maintains bone density, reduces the risk of bone loss and fractures, and preserves muscle mass, contributing to mobility, vitality, and quality of life with age. PureBulk carries numerous calcium supplements, including Calcium Ascorbate (Vitamin C) Powder, Calcium Carbonate (Mineral) Powder, Calcium Citrate (USA) Powder, Calcium D-Glucarate, Calcium Gluconate (USA), Calcium Lactate Gluconate, and Calcium Pyruvate Powder. [97 - 99]
Vitamin D. Vitamin D promotes healthy aging by supporting bone health, immune function, and mood regulation. Adequate vitamin D levels reduce the risk of bone loss and improve immune resilience. Additionally, vitamin D enhances the body's ability to absorb calcium. PureBulk carries Cholecalciferol (Vitamin D3) Powder and Vitamin D3 5000IU Olive Oil (Soy Free) Softgels. [100 - 102]
Zinc. Zinc promotes healthy aging by promoting healthy immune function, wound healing, and hormonal balance. It enhances immune responses, reduces inflammation, and supports metabolic regulation. Zinc becomes even more essential with age, as low levels accelerate aging and decrease immune function in older adults. PureBulk carries numerous zinc supplements. However, Zinc Picolinate 20% and Zinc Bis-Glycinate are best for healthy aging. [103 - 109]
